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cyp2d6 gene locus  (Hmong National Development)

 
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    Hmong National Development cyp2d6 gene locus
    Study Overview. <t>CYP2D6</t> diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.
    Cyp2d6 Gene Locus, supplied by Hmong National Development, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cyp2d6 gene locus/product/Hmong National Development
    Average 90 stars, based on 1 article reviews
    cyp2d6 gene locus - by Bioz Stars, 2026-02
    90/100 stars

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    1) Product Images from "The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping"

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2022.867331

    Study Overview. CYP2D6 diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.
    Figure Legend Snippet: Study Overview. CYP2D6 diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.

    Techniques Used: Sequencing

    CYP2D6 allele count (frequency) in Hmong compared to East Asians.
    Figure Legend Snippet: CYP2D6 allele count (frequency) in Hmong compared to East Asians.

    Techniques Used: Activity Assay

    Comparison of CYP2D6 diplotype frequencies in 48 Hmong with East Asian populations.
    Figure Legend Snippet: Comparison of CYP2D6 diplotype frequencies in 48 Hmong with East Asian populations.

    Techniques Used: Comparison, Activity Assay

    Graphical overview of long-range (XL) PCR fragments generated to characterize gene copy number arrangements and novel allelic variants. Regions amplified from genomic DNA using XL-PCR are represented by gray bars. Selected amplicons were subsequently used as templates to generate sufficient materials for Sanger sequencing (shown in black). Blue boxes downstream of CYP2D6 and CYP2D7 denote highly similar regions; those labeled ‘REP’ contain repetitive sequences. CYP2D7 -derived downstream regions are characterized by the presence of a 1.6 kb “spacer” sequence. See for a comprehensive list of PCR products generated in this study to characterize the alleles. Panel (A–C) describe the summary of XL-PCR products generated to characterize Subject 41, 21, and 10, respectively. All sequence variants found on each of the novel haplotypes are detailed in .
    Figure Legend Snippet: Graphical overview of long-range (XL) PCR fragments generated to characterize gene copy number arrangements and novel allelic variants. Regions amplified from genomic DNA using XL-PCR are represented by gray bars. Selected amplicons were subsequently used as templates to generate sufficient materials for Sanger sequencing (shown in black). Blue boxes downstream of CYP2D6 and CYP2D7 denote highly similar regions; those labeled ‘REP’ contain repetitive sequences. CYP2D7 -derived downstream regions are characterized by the presence of a 1.6 kb “spacer” sequence. See for a comprehensive list of PCR products generated in this study to characterize the alleles. Panel (A–C) describe the summary of XL-PCR products generated to characterize Subject 41, 21, and 10, respectively. All sequence variants found on each of the novel haplotypes are detailed in .

    Techniques Used: Generated, Amplification, Sequencing, Labeling, Derivative Assay

    Summary of the novel allele and suballeles identified in the study. The columns to the left provide nucleotide positions counting from the start of the NG_008376.4 reference sequence and the translation start (ATG = +1), respectively. The dark gray column indicates the reference nucleotide of NG_008376.4 which corresponds to the CYP2D6*1.001 allele definition. “Exon 9 conversion” denotes a CYP2D7- derived region containing several SNPs (details can be found in the structural variant document available on the PharmVar CYP2D 6 gene page at https://www.pharmvar.org/gene/CYP2D6 ).
    Figure Legend Snippet: Summary of the novel allele and suballeles identified in the study. The columns to the left provide nucleotide positions counting from the start of the NG_008376.4 reference sequence and the translation start (ATG = +1), respectively. The dark gray column indicates the reference nucleotide of NG_008376.4 which corresponds to the CYP2D6*1.001 allele definition. “Exon 9 conversion” denotes a CYP2D7- derived region containing several SNPs (details can be found in the structural variant document available on the PharmVar CYP2D 6 gene page at https://www.pharmvar.org/gene/CYP2D6 ).

    Techniques Used: Sequencing, Derivative Assay, Variant Assay

    Comparison of CYP2D6 predicted phenotypes frequencies with other East Asian sub-populations.
    Figure Legend Snippet: Comparison of CYP2D6 predicted phenotypes frequencies with other East Asian sub-populations.

    Techniques Used: Comparison



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    cyp2d6 gene locus  (Hmong National Development)
    90
    Hmong National Development cyp2d6 gene locus
    Study Overview. <t>CYP2D6</t> diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.
    Cyp2d6 Gene Locus, supplied by Hmong National Development, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cyp2d6 gene locus/product/Hmong National Development
    Average 90 stars, based on 1 article reviews
    cyp2d6 gene locus - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Study Overview. CYP2D6 diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: Study Overview. CYP2D6 diplotype was determined using two different approaches: commercial “clinal-grade” testing and via NGS sequencing complemented with CNV analyses (consensus). PGx, pharmacogenetics.

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Sequencing

    CYP2D6 allele count (frequency) in Hmong compared to East Asians.

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: CYP2D6 allele count (frequency) in Hmong compared to East Asians.

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Activity Assay

    Comparison of CYP2D6 diplotype frequencies in 48 Hmong with East Asian populations.

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: Comparison of CYP2D6 diplotype frequencies in 48 Hmong with East Asian populations.

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Comparison, Activity Assay

    Graphical overview of long-range (XL) PCR fragments generated to characterize gene copy number arrangements and novel allelic variants. Regions amplified from genomic DNA using XL-PCR are represented by gray bars. Selected amplicons were subsequently used as templates to generate sufficient materials for Sanger sequencing (shown in black). Blue boxes downstream of CYP2D6 and CYP2D7 denote highly similar regions; those labeled ‘REP’ contain repetitive sequences. CYP2D7 -derived downstream regions are characterized by the presence of a 1.6 kb “spacer” sequence. See for a comprehensive list of PCR products generated in this study to characterize the alleles. Panel (A–C) describe the summary of XL-PCR products generated to characterize Subject 41, 21, and 10, respectively. All sequence variants found on each of the novel haplotypes are detailed in .

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: Graphical overview of long-range (XL) PCR fragments generated to characterize gene copy number arrangements and novel allelic variants. Regions amplified from genomic DNA using XL-PCR are represented by gray bars. Selected amplicons were subsequently used as templates to generate sufficient materials for Sanger sequencing (shown in black). Blue boxes downstream of CYP2D6 and CYP2D7 denote highly similar regions; those labeled ‘REP’ contain repetitive sequences. CYP2D7 -derived downstream regions are characterized by the presence of a 1.6 kb “spacer” sequence. See for a comprehensive list of PCR products generated in this study to characterize the alleles. Panel (A–C) describe the summary of XL-PCR products generated to characterize Subject 41, 21, and 10, respectively. All sequence variants found on each of the novel haplotypes are detailed in .

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Generated, Amplification, Sequencing, Labeling, Derivative Assay

    Summary of the novel allele and suballeles identified in the study. The columns to the left provide nucleotide positions counting from the start of the NG_008376.4 reference sequence and the translation start (ATG = +1), respectively. The dark gray column indicates the reference nucleotide of NG_008376.4 which corresponds to the CYP2D6*1.001 allele definition. “Exon 9 conversion” denotes a CYP2D7- derived region containing several SNPs (details can be found in the structural variant document available on the PharmVar CYP2D 6 gene page at https://www.pharmvar.org/gene/CYP2D6 ).

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: Summary of the novel allele and suballeles identified in the study. The columns to the left provide nucleotide positions counting from the start of the NG_008376.4 reference sequence and the translation start (ATG = +1), respectively. The dark gray column indicates the reference nucleotide of NG_008376.4 which corresponds to the CYP2D6*1.001 allele definition. “Exon 9 conversion” denotes a CYP2D7- derived region containing several SNPs (details can be found in the structural variant document available on the PharmVar CYP2D 6 gene page at https://www.pharmvar.org/gene/CYP2D6 ).

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Sequencing, Derivative Assay, Variant Assay

    Comparison of CYP2D6 predicted phenotypes frequencies with other East Asian sub-populations.

    Journal: Frontiers in Pharmacology

    Article Title: The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping

    doi: 10.3389/fphar.2022.867331

    Figure Lengend Snippet: Comparison of CYP2D6 predicted phenotypes frequencies with other East Asian sub-populations.

    Article Snippet: There is a growing prevalence of medical conditions within the Hmong community for which the prescribed medications are predominately metabolized by CYP2D6 ( ; ; ; ; ; ).

    Techniques: Comparison